Hepatocellular damage due to halothane anaesthesia.
نویسندگان
چکیده
To determine the hepatotoxic effect of halothane anaesthesia, liver function tests were done a day prior to surgery in 41 cases undergoing various elective operations. The tests were repeated on 7th post operative day to see the derangement. Statistically significant rise in serum bilirubin, ALT and alkaline phosphatase was found post-operatively. As certain groups of patients are more prone to develop halothane induced hepatotoxicity, damage in these cases could be prevented by careful pre-operative assessment (JPMA 38: 262 , 1988).
منابع مشابه
Hepatocellular integrity during and after isoflurane and halothane anaesthesia in surgical patients.
Subclinical disturbance in hepatocellular integrity, indicated by glutathione transferase Alpha (GSTA), has been associated with halothane, sevoflurane and propofol, but not with isoflurane anaesthesia. We anaesthetized 82 patients with isoflurane or halothane at 1 MAC for superficial surgery. GSTA concentration were measured with a sensitive time-resolved immunofluorometric assay in serum samp...
متن کاملHepatic damage after exposure to halothane in medical personnel.
Two surgeons, in whom liver damage developed after occupational exposure to sub-anaesthetic doses of halothane, were found to have a circulating antibody which reacted specifically with halothane-altered hepatocyte membrane components. This antibody had been found previously only in those patients in whom severe hepatic necrosis developed after exposure to halothane and in no other form of live...
متن کاملThe Effect of Halothane on the Enzymatic Activity of Mouse Liver and Erythrocyte Glucose- 6-Phosphate Dehydrogenase
219 Abstract: The effects of repeated halothane anaesthesia on 6-10 week old male, Mus musculus albino mice weighing 29-32 g were studied. Halothane, a widely used anaesthetic, is known to be metabolised in the liver to toxic intermediates through cytochrome P4502E1 (CYP2E1). During the first week of repeated dosage, glucose-6phosphate dehydrogenase (G6PDH) activity decreased in both erythrocyt...
متن کاملInduction and recovery characteristics of isoflurane and halothane anaesthesia for short outpatient operations in children.
Induction and recovery characteristics of isoflurane anaesthesia were compared with halothane anaesthesia during outpatient myringotomy and placement of Sheely ventilation tubes in 101 unpremedicated children. Compared with halothane, isoflurane resulted in prolonged induction times and inferior induction scores due to increased salivation, coughing, breathholding and laryngospasm. However, whe...
متن کاملRespiratory and Metabolic Changes during Methoxyflurane and Halothane Anaesthesia.
Respiratory and metabolic changes were studied in twenty normal children during inhalation of 1.5 per cent methoxyflurane or halothane. Both agents caused a significant reduction in pH, and this acidosis was entirely due to a raised Pco2. It was calculated that after 30 minutes anaesthesia the approximate arterial tension of methoxyflurane was 0.3 per cent and that of halothane 0.8 per cent. Si...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 38 10 شماره
صفحات -
تاریخ انتشار 1988